药物科学与工程系

1、纳米载药
纳米技术在药物和功能性食品中的应用，主要是双亲分子自组装纳米体系，用于小分子活性因子的包封、输运以及对生物大分子的结构调控及其递送。
2、天然产物化学
天然活性成分的提取分离、结构改造及活性研究
3、药物化学
阿尔茨海默病的早期诊断分子探针以及治疗药物的研究

1. 靶向淀粉样蛋白的阿尔茨海默病分子探针研究，主持
2. 用于阿尔茨海默病诊断的磁共振显像分子探针，主持
3. 葡萄糖基环保表面活性剂系列产品的研究开发，主持
4. 天然植物艾草活性成分提取分离工艺研究，主持
5. 抗真菌药物艾氟康唑的合成工艺及工业化研究，主持
6. 化妆品中天然活性成分的研究及产业化，主持

代表性论文

1. Tiantian Xu, Jingwen Zhang, Risheng Jin, Rong Cheng, Xiaonan Wang, Chuanxun Yuan, Changsheng Gan*. Physicochemical properties, antioxidant activities and in vitro sustained release behavior of co-encapsulated liposomes as vehicle for vitamin E and β-carotene. Journal of the Science of Food and Agriculture, 2022, 102, 5759-5767

2. Changsheng Gan*, Rong Cheng, Kunliang Cai, Xiaonan Wang, Chenkun Xie, Tiantian Xu, Chuanxun Yuan, Interaction of calf thymus DNA and glucose-based gemini cationic surfactants with different spacer length: A spectroscopy and DLS study, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 267, 120606

3. Rong Cheng, Tiantian Xu, Chao Wang, Changsheng Gan*, The stabilization and antioxidant performances of coenzyme Q10-loaded niosomes coated by PEG and chitosan, Journal of Molecular Liquids, 2021, 325(1), 115194.

4. Kunliang Cai, Rong Cheng, Chao Wang, Yi Xia, Tiantian Xu, Changsheng Gan*, Interactions with ctDNA of novel sugar-based gemini cationic surfactants, International Journal of Biological Macromolecules, 2020, 156, 805-811.

5. Changsheng Gan*, Kunliang Cai, Xilin Qu, Hong Li, Lianggang Wei, Rong Cheng, Glucose-based novel gemini surfactants: Surface activities, aggregation properties and a preliminary study as nanocarrier for resveratrol, Journal of Molecular Liquids 2019, 283, 781-787.

6. Changsheng Gan*, Hong Li, Kunliang Cai. Novel Sugar-Based Gemini Surfactants and Their Surface Properties, Journal of Surfactants and Detergents, 2018, 21, 859-866.

7. Changsheng Gan*, Jingyi Hu, Dou-Dou Nan, Shanshan Wang, Hong Li. Synthesis and biological evaluation of curcumin analogs as β-amyloid imaging agents, Future Medicinal Chemistry, 2017, 9(14), 1587-1596.

8. Changsheng Gan*, Zhenzhen Zhao, Dou-Dou Nan, Binbin Yin, Jingyi Hu. Homoisoflavonoids as potential imaging agents for β-amyloid plaques in Alzheimer’s disease, European Journal of Medicinal Chemistry, 2014, 76, 125-131

9. Changsheng Gan*, Lin Zhou, Zhenzhen Zhao, Haoshu Wang. Benzothiazole Schiff-bases as potential imaging agentsfor β-amyloid plaques in Alzheimer’s disease, Medicinal Chemistry Research, 2013, 22(9), 4069-4074

10. Changsheng Gan*, Haoshu Wang, Zhenzhen Zhao, Binbin Yin. Sugar-Based Ester Quaternary Ammonium Compounds and Their Surfactant Properties, Journal of Surfactants and Detergents, 2014, 17, 465-470

11. Dou-Dou Nan, Chang-Sheng Gan, Chen-Wei Wang, Jin-Ping Qiao, Xin-Meng Wang, Jiang-Ning Zhou*. 6-Methoxy-indanone derivatives as potential probes for β-amyloid plaques in Alzheimer's disease. European Journal of Medicinal Chemistry 2016, 124, 117-128

专利
1.一种以茚酮和吩噻嗪为骨架结构的杂二联体类化合物及用途，专利号：ZL 2011 1 0416785.7

2.一种呫吨酮类衍生物及其用途，专利号：ZL 2011 1 0434209.5

3.一种苯并噻唑类衍生物及其用途，专利号：ZL 2011 1 0434465.4

4.一种葡萄糖酯基季铵盐阳离子表面活性剂及其合成方法，专利号：ZL 2012 1 0261510.5

5.一种葡萄糖基双子阳离子表面活性剂及其合成方法，专利号：ZL 201710010183.9

6.葡萄糖基双子非离子表面活性剂及其合成方法，专利号：ZL 201710932528.6

7.一种葡萄糖基双子非离子表面活性剂、两性表面活性剂及其合成方法，专利号：ZL 201710936090.9

8.一种具有缓解疲劳功能的中药组合物及其应用，申请号：201611004592.X

9.以哌啶酮为核心的具有双查尔酮骨架结构的姜黄素类似物及其衍生物以及应用，专利号：ZL 201711021369.0

1.安徽省科学技术奖三等奖，2011年